Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.55 |
| ▸ | CHUK | O15111 | 1/20 | 0.55 |
| ▸ | DHODH | Q02127 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 4/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6028892 | 0.87 | DHODH (0.59) | IKBKBCHUKDHODHPARP1PDPK1 | |
| SCHEMBL6028632 | 0.84 | DHODH (0.56) | IKBKBCHUKDHODHPARP1JAK2 | |
| SCHEMBL6029671 | 0.84 | DHODH (0.68) | IKBKBCHUKDHODHPARP1PDPK1 | |
| SCHEMBL6028768 | 0.83 | DHODH (0.55) | DHODHPARP1PDPK1HDAC11BTK | |
| SCHEMBL6029180 | 0.83 | DHODH (0.55) | DHODHPARP1PDPK1HDAC11BTK | |
| SCHEMBL6029606 | 0.83 | DHODH (0.78) | IKBKBCHUKDHODHPARP1PDPK1 | |
| SCHEMBL6028084 | 0.82 | DHODH (0.59) | IKBKBCHUKDHODHPARP1PDPK1 | |
| SCHEMBL6028814 | 0.80 | PARP1 (0.57) | IKBKBDHODHPARP1JAK2PDPK1 | |
| SCHEMBL6029836 | 0.80 | DHODH (0.51) | IKBKBCHUKDHODHPARP1PDPK1 | |
| SCHEMBL6029417 | 0.80 | HDAC11 (0.58) | DHODHPARP1JAK2PDPK1HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087637-B2 | Substituted indoles which are PARP inhibitors | BASF AG (DE) | 2006-08-08 | — | — | US | disclosed |
| US-20040067949-A1 | Substituted indoles which are parp inhibitors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2004-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067949-A1 | Substituted indoles which are parp inhibitors | PARP1, PARP2, PARP12 | IKBKB 480/4885CHUK 222/4885DHODH 674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.