Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.56 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.49 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.48 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.48 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3086445 | 0.84 | MAPK14 (0.73) | MAPK14KITLCKKDRMAPK11 | |
| SCHEMBL27642672 | 0.82 | MAPK14 (0.56) | MAPK14MAP2K1KITLCKKDR | |
| SCHEMBL3087207 | 0.81 | MAPK14 (0.61) | MAPK14KITLCKKDRMAPK11 | |
| SCHEMBL13715075 | 0.81 | MAPK14 (0.56) | MAPK14MAP2K1MAPK11HSPB1CYP2C9 | |
| SCHEMBL31367847 | 0.80 | MAPK14 (0.74) | MAPK14KITLCKKDRMAPK11 | |
| SCHEMBL178414 | 0.79 | MAPK14 (0.60) | MAPK14MAPK11HSPB1CYP2C9NPC1 | |
| Hydrochloric Acid SCHEMBL28078 | 0.78 | MAPK14 (0.59) | MAPK14MAPK11HSPB1CYP2C9NPC1 | |
| SCHEMBL1383833 | 0.76 | MAPK14 (0.54) | MAPK14KITLCKKDRMAPK11 | |
| SCHEMBL5630096 | 0.74 | MAPK14 (0.87) | MAPK14LCKKDRMAPK11HSPB1 | |
| SCHEMBL25728178 | 0.74 | MAPK14 (0.73) | MAPK14LCKKDRMAPK11HSPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1687284-A2 | p-38 KINASE INHIBITORS | Novartis AG (CH) | 2006-08-09 | — | — | EP | claimed |
| WO-2005012241-A2 | p-38 KINASE INHIBITORS | NOVARTIS AG (CH) | 2005-02-10 | — | — | WO | claimed |