Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.53 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.53 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.53 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.48 |
| ▸ | MARK3 | P27448 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5073297 | 0.83 | TNKS (0.56) | TNKSMAP4K4PIM1PIM3AURKB | |
| SCHEMBL6029194 | 0.81 | CDC7 (0.57) | CHEK1DHODHKDM4EPARP1HDAC11 | |
| SCHEMBL6028855 | 0.81 | PARP1 (0.52) | CHEK1DHODHKDM4EALDH1A1CHEK2 | |
| SCHEMBL6029990 | 0.80 | PARP1 (0.60) | CHEK1KDRDHODHCHEK2PDGFRB | |
| SCHEMBL6028431 | 0.80 | PARP1 (0.51) | CHEK1DHODHCHEK2PARP1 | |
| SCHEMBL6028989 | 0.80 | PARP1 (0.51) | CHEK1DHODHKDM4EALDH1A1CHEK2 | |
| SCHEMBL6029382 | 0.79 | PARP1 (0.52) | CHEK1DHODHKDM4EALDH1A1CHEK2 | |
| SCHEMBL6028389 | 0.77 | DHODH (0.59) | MAP4K4MAP4K5PKN2CHEK1CSF1R | |
| SCHEMBL6028915 | 0.76 | PARP1 (0.47) | CHEK1KDRDHODHCHEK2PARP1 | |
| SCHEMBL6028044 | 0.76 | DHODH (0.61) | MAP4K4CLK4CHEK1CSF1RKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087637-B2 | Substituted indoles which are PARP inhibitors | BASF AG (DE) | 2006-08-08 | — | — | US | disclosed |
| US-20040067949-A1 | Substituted indoles which are parp inhibitors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2004-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067949-A1 | Substituted indoles which are parp inhibitors | PARP1, PARP2, PARP12 | TNKS 14/4885MAP4K4 1754/4885PIM1 343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.