Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.54 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | IKBKB | O14920 | 10/20 | 0.47 |
| ▸ | CHUK | O15111 | 9/20 | 0.47 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6028084 | 0.83 | DHODH (0.59) | PDPK1DHODHIKBKBCHUKHDAC11 | |
| SCHEMBL5074227 | 0.82 | PI4K2A (0.47) | PDPK1DHODHIKBKBCHUKPI4K2A | |
| SCHEMBL6029606 | 0.79 | DHODH (0.78) | PDPK1DHODHIKBKBCHUKHDAC11 | |
| SCHEMBL6028044 | 0.79 | DHODH (0.61) | PDPK1DHODHHDAC11 | |
| SCHEMBL6028389 | 0.78 | DHODH (0.59) | PDPK1DHODHHDAC11 | |
| SCHEMBL6029671 | 0.78 | DHODH (0.68) | PDPK1DHODHIKBKBCHUKHDAC11 | |
| SCHEMBL6028632 | 0.78 | DHODH (0.56) | PDPK1DHODHIKBKBCHUKHDAC11 | |
| SCHEMBL6028357 | 0.78 | DHODH (0.59) | PDPK1DHODHIKBKBHDAC11 | |
| SCHEMBL6028892 | 0.78 | DHODH (0.59) | PDPK1DHODHIKBKBCHUKHDAC11 | |
| SCHEMBL6029569 | 0.77 | DHODH (0.51) | PDPK1DHODHNPC1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087637-B2 | Substituted indoles which are PARP inhibitors | BASF AG (DE) | 2006-08-08 | — | — | US | disclosed |
| US-20040067949-A1 | Substituted indoles which are parp inhibitors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2004-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067949-A1 | Substituted indoles which are parp inhibitors | PARP1, PARP2, PARP12 | PDPK1 235/4885DHODH 674/4885IKBKB 480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.