Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19616801 | 0.91 | SMN1; SMN2 (0.56) | SMN1; SMN2POLBTP53ALDH1A1OPRM1 | |
| SCHEMBL21851141 | 0.90 | TP53 (0.56) | SMN1; SMN2POLBTP53ALDH1A1OPRM1 | |
| SCHEMBL16695511 | 0.89 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBTP53ALDH1A1OPRM1 | |
| SCHEMBL5068809 | 0.85 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBTP53ALDH1A1OPRM1 | |
| SCHEMBL5068807 | 0.85 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBTP53ALDH1A1OPRM1 | |
| SCHEMBL3274422 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2POLBTP53ALDH1A1OPRM1 | |
| SCHEMBL2942040 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2POLBTP53ALDH1A1OPRM1 | |
| SCHEMBL2942042 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2POLBTP53ALDH1A1OPRM1 | |
| SCHEMBL16217913 | 0.82 | CHRM1 (0.52) | SMN1; SMN2POLBTP53ALDH1A1OPRM1 | |
| SCHEMBL16210548 | 0.82 | SMN1; SMN2 (0.51) | SMN1; SMN2POLBTP53ALDH1A1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060241123-A1 | Substituted piperidine and piperazine derivatives as melanocortin-4 receptor modulators | SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH (CH) | 2006-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241123-A1 | Substituted piperidine and piperazine derivatives as melanocortin-4 receptor modulators | MC4R, MC5R, MC3R | SMN1; SMN2 1508/4885POLB 2972/4885TP53 3386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.