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SCHEMBL6032363

SCHEMBL6032363

CS(=O)(=O)N(CC(=O)N(Cc1ccc(C(=O)NCc2ccc(Oc3ccccc3)cc2)cc1)c1ccc(O)c(C(=O)O)c1)S(C)(=O)=O

nearest known ligand 0.56

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ STAT3 P40763 14/20 0.56
▸ PDK1 Q15118 1/20 0.49
▸ MAPK14 Q16539 3/20 0.48
▸ HPGD P15428 1/20 0.45
▸ BCL2L1 Q07817 1/20 0.44
▸ MCL1 Q07820 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2472685 0.90 STAT3 (0.59) STAT3PDK1MAPK14HPGD
SCHEMBL2469679 0.87 STAT3 (0.64) STAT3PDK1MAPK14HPGD
SCHEMBL2469071 0.85 STAT3 (0.60) STAT3PDK1MAPK14HPGD
SCHEMBL2470433 0.85 STAT3 (0.59) STAT3PDK1MAPK14HPGD
SCHEMBL2471982 0.84 STAT3 (0.74) STAT3PDK1MAPK14HPGD
SCHEMBL2468720 0.82 STAT3 (0.58) STAT3PDK1MAPK14HPGDBCL2L1
SCHEMBL2466208 0.81 STAT3 (0.59) STAT3PDK1MAPK14HPGD
SCHEMBL2470920 0.80 STAT3 (0.57) STAT3PDK1MAPK14HPGD
SCHEMBL2468218 0.80 STAT3 (0.67) STAT3PDK1MAPK14HPGD
SCHEMBL2470921 0.80 STAT3 (0.57) STAT3PDK1MAPK14HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1656139-A1 ARYL DICARBOXAMIDES Applied Research Systems ARS Holding N.V. (AN) 2006-05-17 — — EP claimed
WO-2005011685-A1 ARYL DICARBOXAMIDES APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) 2005-02-10 — — WO claimed