Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT3 | Q9Y243 | 20/20 | 0.61 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | PRKACG | P22612 | 1/20 | 0.43 |
| ▸ | PRKACB | P22694 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | AKT2 | P31751 | 1/20 | 0.43 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4996871 | 0.88 | AKT3 (0.55) | AKT3METKITPRKCAPRKACA | |
| SCHEMBL5000487 | 0.82 | AKT3 (0.55) | AKT3METKITPRKCAPRKACA | |
| SCHEMBL5000473 | 0.81 | AKT3 (0.61) | AKT3METKITPRKCAPRKACA | |
| SCHEMBL5000479 | 0.81 | AKT3 (0.61) | AKT3METKITPRKCAPRKACA | |
| SCHEMBL5006487 | 0.81 | UTS2R (0.52) | AKT3 | |
| SCHEMBL5003908 | 0.81 | AKT3 (0.74) | AKT3 | |
| SCHEMBL13992687 | 0.80 | AKT3 (0.57) | AKT3METKITPRKCAPRKACA | |
| SCHEMBL4918167 | 0.79 | AKT3 (0.65) | AKT3 | |
| SCHEMBL6033215 | 0.78 | AKT3 (0.72) | AKT3METKITPRKCAPRKACA | |
| SCHEMBL5000551 | 0.76 | AKT3 (1.00) | AKT3METKITPRKCAPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732919-A1 | SUBSTITUTED THIOPHENE DERIVATIVES AS ANTI-CANCER AGENTS | CHIRON CORPORATION (US) | 2006-12-20 | — | — | EP | claimed |
| WO-2005095386-A1 | SUBSTITUTED THIOPHENE DERIVATIVES AS ANTI-CANCER AGENTS | CHIRON CORPORATION (US) | 2005-10-13 | — | — | WO | claimed |