Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT3 | Q9Y243 | 19/20 | 0.73 |
| ▸ | MET | P08581 | 1/20 | 0.57 |
| ▸ | KIT | P10721 | 1/20 | 0.57 |
| ▸ | PRKCA | P17252 | 1/20 | 0.57 |
| ▸ | PRKACA | P17612 | 1/20 | 0.57 |
| ▸ | PRKACG | P22612 | 1/20 | 0.57 |
| ▸ | PRKACB | P22694 | 1/20 | 0.57 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.57 |
| ▸ | AKT1 | P31749 | 1/20 | 0.57 |
| ▸ | AKT2 | P31751 | 1/20 | 0.57 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.57 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6032629 | 0.87 | AKT3 (0.75) | AKT3METKITPRKCAPRKACA | |
| SCHEMBL4926792 | 0.86 | AKT3 (0.81) | AKT3METKITPRKCAPRKACA | |
| SCHEMBL5000551 | 0.85 | AKT3 (1.00) | AKT3METKITPRKCAPRKACA | |
| SCHEMBL5000535 | 0.84 | AKT3 (0.79) | AKT3METKITPRKCAPRKACA | |
| SCHEMBL5000410 | 0.84 | AKT3 (0.79) | AKT3METKITPRKCAPRKACA | |
| SCHEMBL5004022 | 0.82 | AKT3 (0.78) | AKT3METKITPRKCAPRKACA | |
| SCHEMBL5000293 | 0.81 | AKT3 (0.81) | AKT3METKITPRKCAPRKACA | |
| SCHEMBL5003668 | 0.81 | AKT3 (0.79) | AKT3METKITPRKCAPRKACA | |
| SCHEMBL5000473 | 0.81 | AKT3 (0.61) | AKT3METKITPRKCAPRKACA | |
| SCHEMBL5000479 | 0.81 | AKT3 (0.61) | AKT3METKITPRKCAPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732919-A1 | SUBSTITUTED THIOPHENE DERIVATIVES AS ANTI-CANCER AGENTS | CHIRON CORPORATION (US) | 2006-12-20 | — | — | EP | claimed |
| WO-2005095386-A1 | SUBSTITUTED THIOPHENE DERIVATIVES AS ANTI-CANCER AGENTS | CHIRON CORPORATION (US) | 2005-10-13 | — | — | WO | claimed |