Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 16/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6033587 | 0.94 | TRPV1 (0.59) | TRPV1EGFREPHX2DHODHABL1 | |
| SCHEMBL5820279 | 0.82 | TRPV1 (0.56) | TRPV1 | |
| SCHEMBL6034095 | 0.82 | TRPV1 (0.53) | TRPV1EGFREPHX2DHODHABL1 | |
| SCHEMBL6033679 | 0.80 | TRPV1 (0.58) | TRPV1EPHX2 | |
| SCHEMBL5814644 | 0.73 | TRPV1 (0.62) | TRPV1EGFREPHX2 | |
| SCHEMBL6033619 | 0.73 | TRPV1 (0.46) | TRPV1EGFREPHX2DHODH | |
| SCHEMBL5800155 | 0.72 | TRPV1 (0.58) | TRPV1 | |
| SCHEMBL6033658 | 0.72 | TRPV1 (0.60) | TRPV1 | |
| SCHEMBL5739760 | 0.71 | TRPV1 (0.60) | TRPV1EGFREPHX2 | |
| SCHEMBL4973865 | 0.70 | TRPV1 (1.00) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685124-A1 | SUBSTITUTED NITROGEN-CONTAINING SIX-MEMBERED AMINO-HETEROCYCLES AS VANILLOID-1 RECEPTOR ANTAGONISTS FOR TREATING PAIN | MERCK SHARP & DOHME LTD. (GB) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005047279-A1 | SUBSTITUTED NITROGEN-CONTAINING SIX-MEMBERED AMINO-HETEROCYCLES AS VANILLOID-1 RECEPTOR ANTAGONISTS FOR TREATING PAIN | MERCK SHARP & DOHME LIMITED (GB) | 2005-05-26 | — | — | WO | disclosed |