Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 20/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6249602 | 0.92 | TRPV1 (0.58) | TRPV1 | |
| SCHEMBL6253017 | 0.87 | TRPV1 (0.65) | TRPV1 | |
| SCHEMBL6033658 | 0.82 | TRPV1 (0.60) | TRPV1 | |
| SCHEMBL5813868 | 0.81 | TRPV1 (0.59) | TRPV1 | |
| SCHEMBL5802054 | 0.80 | TRPV1 (0.58) | TRPV1 | |
| SCHEMBL5800155 | 0.80 | TRPV1 (0.58) | TRPV1 | |
| SCHEMBL6033679 | 0.80 | TRPV1 (0.58) | TRPV1 | |
| SCHEMBL5798974 | 0.79 | TRPV1 (0.60) | TRPV1 | |
| SCHEMBL5815210 | 0.78 | TRPV1 (0.56) | TRPV1 | |
| SCHEMBL6033606 | 0.78 | TRPV1 (0.55) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685124-A1 | SUBSTITUTED NITROGEN-CONTAINING SIX-MEMBERED AMINO-HETEROCYCLES AS VANILLOID-1 RECEPTOR ANTAGONISTS FOR TREATING PAIN | MERCK SHARP & DOHME LTD. (GB) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005047279-A1 | SUBSTITUTED NITROGEN-CONTAINING SIX-MEMBERED AMINO-HETEROCYCLES AS VANILLOID-1 RECEPTOR ANTAGONISTS FOR TREATING PAIN | MERCK SHARP & DOHME LIMITED (GB) | 2005-05-26 | — | — | WO | disclosed |