Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.82 |
| ▸ | CDK1 | P06493 | 12/20 | 0.77 |
| ▸ | AURKA | O14965 | 1/20 | 0.65 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | CDK9 | P50750 | 1/20 | 0.58 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6033918 | 0.90 | KDR (1.00) | KDRCDK1ALDH1A1ALOX15RAB9A | |
| SCHEMBL31061561 | 0.87 | KDR (1.00) | KDRCDK1ALDH1A1ALOX15RAB9A | |
| SCHEMBL6034228 | 0.84 | KDR (1.00) | KDRCDK1 | |
| SCHEMBL24477844 | 0.84 | KDR (0.58) | KDRCDK1AURKACCNT1CCNA2 | |
| SCHEMBL6034237 | 0.84 | KDR (0.76) | KDRCDK1ALDH1A1ALOX15RAB9A | |
| SCHEMBL6034268 | 0.83 | KDR (0.74) | KDRCDK1ALDH1A1ALOX15RAB9A | |
| SCHEMBL6033811 | 0.83 | KDR (0.74) | KDRCDK1 | |
| SCHEMBL24477853 | 0.83 | KDR (0.76) | KDRCDK1AURKACCNT1CCNA2 | |
| SCHEMBL24478147 | 0.83 | KDR (0.74) | KDRCDK1CCNT1CCNA2CDK2 | |
| SCHEMBL6033235 | 0.82 | KDR (0.72) | KDRCDK1ALDH1A1ALOX15RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187816-B1 | 5-CYANO-2-AMINOPYRIMIDINE DERIVATIVES | CELLTECH R&D LTD (GB) | 2006-12-20 | — | — | EP | disclosed |
| US-6579983-B1 | Potent and selective inhibitors of receptor tyrosine kinases involved in angiogenesis, especially KDR kinase and/or FGFr kinase | CELLTECH R&D LIMITED (GB) | 2003-06-17 | — | — | US | disclosed |
| US-20020147339-A1 | 5-cyano-2-aminopyrimidine derivatives | CELLTECH R&D LIMITED (GB) | 2002-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020147339-A1 | 5-cyano-2-aminopyrimidine derivatives | FLT1, FGFR1, KDR | KDR 3/4885CDK1 59/4885AURKA 225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.