Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.53 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.49 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.48 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.47 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6038017 | 0.95 | IDO1 (0.52) | IDO1SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL6038019 | 0.95 | IDO1 (0.52) | IDO1SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL18413846 | 0.90 | IDO1 (0.53) | IDO1SIRT5ITGB3ITGA2BPSMB8 | |
| SCHEMBL6038186 | 0.87 | IDO1 (0.55) | IDO1 | |
| SCHEMBL20154776 | 0.85 | IDO1 (0.57) | IDO1PSMB8PSMB9PSMB5 | |
| SCHEMBL18395634 | 0.85 | IDO1 (0.57) | IDO1PSMB8PSMB9PSMB5 | |
| SCHEMBL18395958 | 0.84 | TACR1 (0.47) | IDO1ITGB3ITGA2B | |
| SCHEMBL18395955 | 0.84 | TACR1 (0.47) | IDO1ITGB3ITGA2B | |
| SCHEMBL18407273 | 0.83 | IDO1 (0.47) | IDO1 | |
| SCHEMBL22750125 | 0.82 | PTGER4 (0.64) | SIRT5SIRT2SIRT1SIRT3ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264415-A1 | Inhibitors of histone deacetylase | METHYLGENE INC. | 2006-11-23 | — | — | US | disclosed |
| WO-2006102760-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2006-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264415-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC3, HDAC11 | IDO1 1132/4885SIRT5 155/4885SIRT2 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.