Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6038190 | 0.79 | ADORA2A (0.43) | MAPTMAPK1HTTNPSR1L3MBTL1 | |
| SCHEMBL5024955 | 0.78 | MAPT (0.52) | MAPTMAPK1HTTNPSR1L3MBTL1 | |
| SCHEMBL5022506 | 0.74 | ADORA1 (0.51) | MAPTMAPK1HTTNPSR1L3MBTL1 | |
| SCHEMBL1733531 | 0.70 | MAPK1 (0.61) | MAPTMAPK1HTTNPSR1L3MBTL1 | |
| SCHEMBL6038234 | 0.67 | ADORA2A (0.39) | HPGDALDH1A1ADORA2AADORA1 | |
| SCHEMBL6038204 | 0.65 | KDM4E (0.38) | MAPTMAPK1NPSR1L3MBTL1KMT2A | |
| SCHEMBL5022217 | 0.64 | MAPT (0.56) | MAPTMAPK1HTTNPSR1L3MBTL1 | |
| SCHEMBL2126019 | 0.64 | HDAC3 (0.46) | MAPTKMT2AKDM4EHPGDALDH1A1 | |
| SCHEMBL30527141 | 0.64 | MKNK1 (0.65) | CYP19A1KMT2ARXFP1MKNK1MKNK2 | |
| SCHEMBL83186 | 0.63 | RECQL (0.62) | CYP19A1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697351-A1 | 2,6-BISHETEROARYL-4-AMINOPYRIMIDINES AS ADENOSINE RECEPTOR ANTAGONISTS | Almirall Prodesfarma AG (CH) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058883-A1 | 2, 6 BISHETEROARYL-4-AMINOPYRIMIDINES AS ADENOSINE RECEPTOR ANTAGONISTS | ALMIRALL PRODESFARMA AG (CH) | 2005-06-30 | — | — | WO | disclosed |