Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 16/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 14/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5016168 | 1.00 | ADORA2A (0.41) | ADORA2AADORA1ADORA3ADORA2BGBA1 | |
| SCHEMBL5017845 | 0.80 | GBA1 (0.42) | ADORA2AADORA1ADORA3ADORA2BGBA1 | |
| SCHEMBL5016105 | 0.80 | ADORA2A (0.65) | ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL27661590 | 0.80 | ADORA2A (0.48) | ADORA2AADORA1ADORA3ADORA2BPRNP | |
| SCHEMBL5016218 | 0.79 | ADORA2A (0.67) | ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL28760739 | 0.79 | ADORA2A (0.66) | ADORA2AADORA1ADORA3ADORA2BTDP1 | |
| SCHEMBL5024947 | 0.79 | ADORA2A (0.66) | ADORA2AADORA1ADORA3ADORA2BTDP1 | |
| SCHEMBL5022445 | 0.78 | ADORA2A (0.53) | ADORA2AADORA1ADORA3ADORA2BPRNP | |
| SCHEMBL5022327 | 0.78 | ADORA2A (0.50) | ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL5016142 | 0.78 | ADORA2A (0.39) | ADORA2AADORA1ADORA3ADORA2BGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1953975-A | 2, 6 bisheteroaryl-4-aminopyrimidines as adenosine receptor antagonists | ALMIRALL PRODESFARMA AG (CH) | 2007-04-25 | — | — | CN | disclosed |
| EP-1697351-A1 | 2,6-BISHETEROARYL-4-AMINOPYRIMIDINES AS ADENOSINE RECEPTOR ANTAGONISTS | Almirall Prodesfarma AG (CH) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058883-A1 | 2, 6 BISHETEROARYL-4-AMINOPYRIMIDINES AS ADENOSINE RECEPTOR ANTAGONISTS | ALMIRALL PRODESFARMA AG (CH) | 2005-06-30 | — | — | WO | disclosed |