Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 10/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.45 |
| ▸ | MYC | P01106 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | F12 | P00748 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5613049 | 0.79 | ADORA2A (0.52) | ADORA2AADORA1MYCLMNAMAPT | |
| SCHEMBL5016281 | 0.78 | ADORA2A (0.60) | ADORA2AADORA1LMNASMN1; SMN2MAPK1 | |
| SCHEMBL5023009 | 0.76 | MAPT (0.51) | ADORA2AADORA1LMNASMN1; SMN2MAPK1 | |
| SCHEMBL5022257 | 0.72 | ADORA2A (0.55) | ADORA2AADORA1MYCLMNASMN1; SMN2 | |
| SCHEMBL5613051 | 0.71 | ADORA2A (0.53) | ADORA2AADORA1MYCLMNAMAPT | |
| SCHEMBL5025068 | 0.69 | MAPT (0.56) | ADORA2AADORA1MYCLMNASMN1; SMN2 | |
| SCHEMBL5026233 | 0.69 | ADORA2A (0.53) | ADORA2AADORA1MYCLMNASMN1; SMN2 | |
| SCHEMBL5016124 | 0.68 | ADORA2A (0.50) | ADORA2AADORA1MYCMAPTALDH1A1 | |
| SCHEMBL5017710 | 0.67 | ADORA2A (0.73) | ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL6038347 | 0.67 | KMT2A (0.42) | ADORA2ALMNASMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697351-A1 | 2,6-BISHETEROARYL-4-AMINOPYRIMIDINES AS ADENOSINE RECEPTOR ANTAGONISTS | Almirall Prodesfarma AG (CH) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058883-A1 | 2, 6 BISHETEROARYL-4-AMINOPYRIMIDINES AS ADENOSINE RECEPTOR ANTAGONISTS | ALMIRALL PRODESFARMA AG (CH) | 2005-06-30 | — | — | WO | disclosed |