Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 9/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.47 |
| ▸ | ADA | P00813 | 6/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6038249 | 0.78 | ADORA2A (0.53) | ADORA2AADORA1ADORA3ADORA2BF2 | |
| SCHEMBL27661596 | 0.78 | ADORA2A (0.58) | ADORA2AADORA1ADORA3ADORA2BF2 | |
| SCHEMBL6038240 | 0.76 | ADORA2A (0.46) | ADORA2AADORA1ADORA3ADORA2BF2 | |
| SCHEMBL6038267 | 0.75 | ADORA2A (0.57) | ADORA2AADORA1ADORA3ADORA2BF2 | |
| SCHEMBL6038275 | 0.74 | ADORA2A (0.64) | ADORA2AADORA1ADORA3ADORA2BF2 | |
| SCHEMBL27661823 | 0.74 | ADORA2A (0.64) | ADORA2AADORA1ADORA3ADORA2BF2 | |
| SCHEMBL5612886 | 0.74 | ADORA2A (0.80) | ADORA2AADORA1ADORA3ADORA2BMAPT | |
| SCHEMBL6038256 | 0.74 | ADORA2A (0.55) | ADORA2AADORA1ADORA3ADORA2BF2 | |
| SCHEMBL5017715 | 0.74 | ADORA2A (0.69) | ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL5017911 | 0.73 | ADORA2A (0.79) | ADORA2AADORA1ADORA3ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697351-A1 | 2,6-BISHETEROARYL-4-AMINOPYRIMIDINES AS ADENOSINE RECEPTOR ANTAGONISTS | Almirall Prodesfarma AG (CH) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058883-A1 | 2, 6 BISHETEROARYL-4-AMINOPYRIMIDINES AS ADENOSINE RECEPTOR ANTAGONISTS | ALMIRALL PRODESFARMA AG (CH) | 2005-06-30 | — | — | WO | disclosed |