Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 16/20 | 0.77 |
| ▸ | MAPK8 | P45983 | 15/20 | 0.77 |
| ▸ | MAPK9 | P45984 | 15/20 | 0.77 |
| ▸ | JUN | P05412 | 14/20 | 0.77 |
| ▸ | MAPK10 | P53779 | 11/20 | 0.77 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.65 |
| ▸ | CCNK | O75909 | 5/20 | 0.65 |
| ▸ | CDK9 | P50750 | 5/20 | 0.65 |
| ▸ | CDK12 | Q9NYV4 | 5/20 | 0.65 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.65 |
| ▸ | CDK7 | P50613 | 4/20 | 0.65 |
| ▸ | CCNH | P51946 | 3/20 | 0.65 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.65 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6039569 | 0.94 | CDK2 (0.72) | CDK2MAPK8MAPK9JUNMAPK10 | |
| SCHEMBL6039238 | 0.94 | MAPK8 (0.79) | CDK2MAPK8MAPK9JUNMAPK10 | |
| SCHEMBL6039768 | 0.92 | MAPK8 (0.77) | CDK2MAPK8MAPK9JUNMAPK10 | |
| SCHEMBL6039678 | 0.91 | MAPK8 (0.75) | CDK2MAPK8MAPK9JUNMAPK10 | |
| SCHEMBL6039868 | 0.90 | MAPK8 (0.73) | CDK2MAPK8MAPK9JUNMAPK10 | |
| SCHEMBL6039478 | 0.90 | MAPK8 (0.73) | CDK2MAPK8MAPK9JUNMAPK10 | |
| SCHEMBL6040016 | 0.90 | CDK2 (0.80) | CDK2MAPK8MAPK9JUNMAPK10 | |
| SCHEMBL6039309 | 0.88 | MAPK8 (0.92) | CDK2MAPK8MAPK9JUNMAPK10 | |
| SCHEMBL6039388 | 0.88 | MAPK8 (0.82) | CDK2MAPK8MAPK9JUNMAPK10 | |
| SCHEMBL6039400 | 0.88 | MAPK8 (0.71) | CDK2MAPK8MAPK9JUNMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038001-A1 | AMINOPYRIMIDINE DERIVATIVES AS JNK INHIBITORS | CELLTECH R & D LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |