Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.66 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.66 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.66 |
| ▸ | JUN | P05412 | 1/20 | 0.66 |
| ▸ | IGF1R | P08069 | 18/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | CDK7 | P50613 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | INSR | P06213 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6039664 | 0.83 | MAPK9 (0.72) | CDK2MAPK8MAPK9JUNIGF1R | |
| SCHEMBL22228839 | 0.81 | CDK2 (0.64) | CDK2MAPK8MAPK9JUNIGF1R | |
| SCHEMBL22252929 | 0.81 | CDK2 (0.64) | CDK2MAPK8MAPK9JUNIGF1R | |
| SCHEMBL31500953 | 0.81 | CDK2 (0.64) | CDK2MAPK8MAPK9JUNIGF1R | |
| SCHEMBL6039275 | 0.80 | CDK2 (0.70) | CDK2MAPK8MAPK9JUNCDK7 | |
| SCHEMBL6039253 | 0.80 | MAPK10 (0.73) | CDK2MAPK8MAPK9JUNIGF1R | |
| SCHEMBL22228853 | 0.80 | CDK2 (0.59) | CDK2MAPK8MAPK9JUNIGF1R | |
| SCHEMBL31500962 | 0.80 | CDK2 (0.59) | CDK2MAPK8MAPK9JUNIGF1R | |
| SCHEMBL21027484 | 0.74 | IGF1R (0.56) | CDK2MAPK8MAPK9JUNIGF1R | |
| SCHEMBL20468460 | 0.74 | CDK2 (0.56) | CDK2MAPK8MAPK9JUNIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038001-A1 | AMINOPYRIMIDINE DERIVATIVES AS JNK INHIBITORS | CELLTECH R & D LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |