Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 9/20 | 0.69 |
| ▸ | MAPK9 | P45984 | 9/20 | 0.69 |
| ▸ | CDK2 | P24941 | 5/20 | 0.69 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.69 |
| ▸ | JUN | P05412 | 2/20 | 0.69 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.64 |
| ▸ | IGF1R | P08069 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6039787 | 0.83 | MAPK8 (0.70) | MAPK8MAPK9CDK2MAPK10JUN | |
| SCHEMBL6039564 | 0.81 | MAPK9 (0.74) | MAPK8MAPK9CDK2MAPK10JUN | |
| SCHEMBL6039801 | 0.80 | IRAK4 (0.71) | MAPK8MAPK9CDK2MAPK10JUN | |
| SCHEMBL183898 | 0.79 | MAPK8 (1.00) | MAPK8MAPK9CDK2MAPK10JUN | |
| SCHEMBL7888011 | 0.79 | MAPK8 (1.00) | MAPK8MAPK9CDK2MAPK10JUN | |
| SCHEMBL21067872 | 0.78 | MAPK10 (1.00) | MAPK8MAPK9CDK2MAPK10JUN | |
| SCHEMBL6039780 | 0.77 | MAPK9 (0.66) | MAPK8MAPK9CDK2MAPK10JUN | |
| SCHEMBL18427775 | 0.77 | IRAK4 (1.00) | MAPK8MAPK9CDK2MAPK10JUN | |
| SCHEMBL6039664 | 0.76 | MAPK9 (0.72) | MAPK8MAPK9CDK2MAPK10JUN | |
| SCHEMBL6039892 | 0.75 | MAPK9 (0.63) | MAPK8MAPK9CDK2MAPK10JUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038001-A1 | AMINOPYRIMIDINE DERIVATIVES AS JNK INHIBITORS | CELLTECH R & D LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |