Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | F13A1 | P00488 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136088 | 0.84 | KDM4E (0.44) | KDM4EMAPK1HIF1ATSHRPAOX | |
| SCHEMBL12407913 | 0.84 | KDM4E (0.60) | KDM4EMAPK1HIF1ATSHRPAOX | |
| SCHEMBL21089233 | 0.84 | KDM4E (0.60) | KDM4EMAPK1HIF1ATSHRPAOX | |
| SCHEMBL6130978 | 0.84 | KDM4E (0.60) | KDM4EMAPK1HIF1ATSHRPAOX | |
| SCHEMBL13398529 | 0.84 | KDM4E (0.60) | KDM4EMAPK1HIF1ATSHRPAOX | |
| SCHEMBL868382 | 0.81 | — | — | |
| SCHEMBL8107 | 0.81 | KDM4E (0.71) | KDM4EMAPK1HIF1ATSHRPAOX | |
| SCHEMBL429526 | 0.77 | — | — | |
| SCHEMBL293767 | 0.77 | — | — | |
| SCHEMBL23462877 | 0.76 | KDM4E (0.52) | KDM4EMAPK1HIF1ATSHRPAOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038001-A1 | AMINOPYRIMIDINE DERIVATIVES AS JNK INHIBITORS | CELLTECH R & D LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |