Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.66 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.43 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19117524 | 0.78 | DYRK1A (0.51) | DYRK1AGSK3BNFATC1SLC6A4IMPDH2 | |
| SCHEMBL31049259 | 0.78 | DYRK1A (0.51) | DYRK1AGSK3BNFATC1SLC6A4IMPDH2 | |
| SCHEMBL25217179 | 0.78 | DYRK1A (0.64) | DYRK1AGSK3BNFATC1SLC6A4IMPDH2 | |
| SCHEMBL28875569 | 0.78 | DYRK1A (0.51) | DYRK1AGSK3BNFATC1SLC6A4IMPDH2 | |
| SCHEMBL29314342 | 0.78 | DYRK1A (0.59) | DYRK1AGSK3BSLC6A4IMPDH2 | |
| SCHEMBL24329052 | 0.77 | DYRK1A (0.51) | DYRK1AGSK3BNFATC1SLC6A4IMPDH2 | |
| SCHEMBL24096861 | 0.75 | DYRK1A (0.49) | DYRK1AGSK3BIMPDH2IMPDH1LRRK2 | |
| SCHEMBL1420660 | 0.74 | TRIM24 (0.58) | DYRK1AGSK3BNFATC1SLC6A4IMPDH2 | |
| SCHEMBL31302760 | 0.73 | DYRK1A (0.46) | DYRK1AGSK3BNFATC1SLC6A4IMPDH2 | |
| SCHEMBL21754248 | 0.72 | DYRK1A (0.44) | DYRK1AIMPDH2IMPDH1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038001-A1 | AMINOPYRIMIDINE DERIVATIVES AS JNK INHIBITORS | CELLTECH R & D LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |