Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 20/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.55 |
| ▸ | JUN | P05412 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6039443 | 0.89 | MAPK8 (0.59) | MAPK8MAPK9JUNCDK2MAPK10 | |
| SCHEMBL6039567 | 0.84 | MAPK8 (0.59) | MAPK8MAPK9JUNCDK2MAPK10 | |
| SCHEMBL6039410 | 0.84 | MAPK8 (0.59) | MAPK8MAPK9JUNCDK2MAPK10 | |
| SCHEMBL6040015 | 0.84 | MAPK8 (0.53) | MAPK8MAPK9JUNCDK2MAPK10 | |
| SCHEMBL3826187 | 0.82 | MAPK8 (0.69) | MAPK8MAPK9MAPK10 | |
| SCHEMBL6039354 | 0.82 | MAPK8 (0.59) | MAPK8MAPK9JUNCDK2MAPK10 | |
| SCHEMBL5094133 | 0.82 | MAPK8 (0.69) | MAPK8MAPK9MAPK10 | |
| SCHEMBL3471867 | 0.81 | MAPK8 (0.50) | MAPK8MAPK9JUNCDK2MAPK10 | |
| SCHEMBL13638681 | 0.77 | MAPK8 (0.48) | MAPK8MAPK9MAPK10 | |
| SCHEMBL3819610 | 0.77 | MAPK8 (0.65) | MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038001-A1 | AMINOPYRIMIDINE DERIVATIVES AS JNK INHIBITORS | CELLTECH R & D LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |