Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 16/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL606055 | 0.86 | HRH4 (0.54) | HRH4ADORA2AADORA1HRH3KCNH2 | |
| SCHEMBL1774373 | 0.77 | HRH4 (0.60) | HRH4HRH3KCNH2HRH1HRH2 | |
| SCHEMBL602330 | 0.74 | HRH4 (0.56) | HRH4ADORA2AADORA1HRH3HRH2 | |
| SCHEMBL3430563 | 0.73 | HRH4 (0.54) | HRH4 | |
| SCHEMBL613451 | 0.73 | HRH4 (0.50) | HRH4HRH3KCNH2HRH1HRH2 | |
| Hydrochloric Acid SCHEMBL605480 | 0.73 | HRH4 (0.56) | HRH4ADORA2AADORA1HRH3HRH2 | |
| SCHEMBL1774855 | 0.73 | HRH4 (0.52) | HRH4HRH3KCNH2HRH1HRH2 | |
| SCHEMBL614931 | 0.73 | HRH4 (0.87) | HRH4HRH3KCNH2HRH1HRH2 | |
| SCHEMBL605428 | 0.72 | HRH4 (0.61) | HRH4ADORA2AADORA1HRH3 | |
| Hydrochloric Acid SCHEMBL6512235 | 0.71 | HRH3 (0.63) | HRH4ADORA2AADORA1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005054239-A1 | 2-AMINOPYRIMIDINE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2005-06-16 | — | — | WO | claimed |
| EP-3378476-A1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | Sensorion (FR) | 2018-09-26 | — | — | EP | disclosed |
| US-9688989-B2 | H4 receptor inhibitors for treating tinnitus | SENSORION (FR) | 2017-06-27 | — | — | US | disclosed |
| EP-3130376-A1 | SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2017-02-15 | — | — | EP | disclosed |
| US-9526725-B2 | Selective histamine H4 receptor antagonists for the treatment of vestibular disorders | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2016-12-27 | — | — | US | disclosed |
| EP-2382013-B1 | SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS. | INSERM INST NAT DE LA SANTÉ ET DE LA RECH MÉDICALE (FR) | 2016-07-13 | — | — | EP | disclosed |
| US-20150176010-A1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | SENSORION (FR) | 2015-06-25 | — | — | US | disclosed |
| US-20120039913-A1 | Selective Histamine H4 Receptor Antagonists for the Treatment of Vestibular Disorders | INSERM (institut National de la Sante de la Recher Medicale) (FR) | 2012-02-16 | — | — | US | disclosed |
| EP-2382013-A1 | SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS. | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010072829-A1 | SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS. | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2010-07-01 | — | — | WO | disclosed |
| WO-2005054239-A1 | 2-AMINOPYRIMIDINE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2005-06-16 | — | — | WO | disclosed |