Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 10/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6046827 | 0.83 | CHEK1 (0.46) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL6046810 | 0.83 | CHEK1 (0.46) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL6046714 | 0.82 | CHEK1 (0.43) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL6046752 | 0.82 | CHEK1 (0.43) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL6046774 | 0.82 | CHEK1 (0.45) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL6046798 | 0.81 | CHEK1 (0.48) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL6046718 | 0.79 | CHEK1 (0.43) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL6046795 | 0.78 | CHEK1 (0.43) | CHEK1KCNH2CYP1A2CYP2C19IDO1 | |
| SCHEMBL6046872 | 0.78 | CHEK1 (0.47) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL6046717 | 0.77 | CHEK1 (0.52) | CHEK1KCNH2AURKAKDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060035920-A1 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035920-A1 | Chk-1 inhibitors | CHKA, CHKB, CHEK1 | CHEK1 3/4885KCNH2 3052/4885AURKA 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.