Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.56 |
| ▸ | KDR | P35968 | 14/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | FLT4 | P35916 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 13/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 13/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 13/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 13/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 13/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 13/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 13/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 13/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6046884 | 0.81 | KDR (0.63) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL5911530 | 0.79 | EGFR (0.80) | EGFRKDRFGFR1FLT1RET | |
| Hydrochloric Acid SCHEMBL5911595 | 0.78 | EGFR (0.80) | EGFRKDRFGFR1FLT1RET | |
| SCHEMBL5911655 | 0.77 | EGFR (0.86) | EGFRKDRFLT4 | |
| Hydrochloric Acid SCHEMBL5911498 | 0.76 | EGFR (0.84) | EGFRKDRFLT4 | |
| SCHEMBL7864752 | 0.74 | FLT1 (0.83) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL4109645 | 0.74 | KDR (0.80) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL14863005 | 0.73 | EGFR (0.84) | EGFRKDRFLT4 | |
| SCHEMBL1468310 | 0.73 | FLT1 (0.85) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL8258194 | 0.73 | EGFR (0.83) | EGFRKDRFGFR1FLT1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633365-A1 | MACROCYCLIC QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004105765-A1 | MACROCYCLIC QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-12-09 | — | — | WO | disclosed |