Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 9/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | RARA | P10276 | 2/20 | 0.53 |
| ▸ | RARB | P10826 | 2/20 | 0.53 |
| ▸ | RARG | P13631 | 1/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.48 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1790712 | 0.83 | GCK (0.77) | GCKMEN1KMT2ARARARARB | |
| SCHEMBL1791977 | 0.82 | GCK (1.00) | GCKMEN1KMT2ARARARARB | |
| SCHEMBL2666298 | 0.81 | GCK (0.84) | GCKMEN1KMT2ARARARARB | |
| SCHEMBL2664594 | 0.81 | GCK (0.76) | GCKMEN1KMT2ARARARARB | |
| SCHEMBL2652506 | 0.79 | GCK (0.81) | GCKMEN1KMT2ARARARARB | |
| SCHEMBL1793859 | 0.79 | GCK (0.73) | GCKMEN1KMT2ARARARARB | |
| SCHEMBL1790940 | 0.78 | GCK (0.72) | GCKMEN1KMT2ARARARARB | |
| SCHEMBL2662783 | 0.78 | GCK (0.64) | GCKMEN1KMT2ARARARARB | |
| SCHEMBL2664859 | 0.77 | GCK (0.71) | GCKMEN1KMT2ARARARARB | |
| SCHEMBL2664857 | 0.77 | GCK (0.71) | GCKMEN1KMT2ARARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1695705-A1 | Compounds effecting glucokinase | AstraZeneca AB (SE) | 2006-08-30 | — | — | EP | disclosed |