Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SCN4A | P35499 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.50 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.50 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.50 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.50 |
| ▸ | HEXA | P06865 | 3/20 | 0.44 |
| ▸ | HEXB | P07686 | 3/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 4/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 6/20 | 0.42 |
| ▸ | DHFR | P00374 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL310324 | 0.85 | CYP2D6 (0.50) | CYP2D6ADRA1AMAOAMAPK1SCN4A | |
| SCHEMBL6049489 | 0.85 | HEXA (0.62) | CYP2D6ADRA1AMAOAMAPK1SCN4A | |
| SCHEMBL29384947 | 0.85 | CYP2D6 (0.50) | CYP2D6ADRA1AMAOAMAPK1SCN4A | |
| SCHEMBL5072676 | 0.85 | CYP2D6 (0.47) | CYP2D6ADRA1AMAOAMAPK1SCN4A | |
| Hydrochloric Acid SCHEMBL7767228 | 0.84 | CYP2D6 (0.49) | CYP2D6ADRA1AMAOAMAPK1SCN4A | |
| SCHEMBL5566857 | 0.83 | CYP2D6 (0.48) | CYP2D6ADRA1AMAOAMAPK1SCN4A | |
| SCHEMBL5069251 | 0.82 | HEXA (0.48) | CYP2D6ADRA1AMAOAMAPK1SCN4A | |
| SCHEMBL6049518 | 0.81 | SCN2A (0.43) | CYP2D6ADRA1ASCN5ASCN9ASCN2A | |
| SCHEMBL6049459 | 0.80 | CYP2D6 (0.54) | CYP2D6ADRA1AMAOAMAPK1SCN4A | |
| SCHEMBL6049519 | 0.80 | CYP1A2 (0.57) | CYP2D6ADRA1AMAOAMAPK1SCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0879230-B1 | OPTICALLY ACTIVE PHENYL PYRIMIDINE DERIVATIVE AS ANALGESIC AGENT | GLAXO GROUP LTD (GB) | 2001-07-25 | — | — | EP | claimed |
| US-6124308-A | ANALGESICS, ANTICONVULSANTS, TREATING IRRITABLE BOWEL SYNDROME OR BIPOLAR DISORDER | GLAXO WELLCOME INC. (US) | 2000-09-26 | — | — | US | claimed |
| EP-0879230-A2 | OPTICALLY ACTIVE PHENYL PYRIMIDINE DERIVATIVE AS ANALGESIC AGENT | GLAXO GROUP LIMITED (GB) | 1998-11-25 | — | — | EP | claimed |
| WO-1997009317-A2 | OPTICALLY ACTIVE PHENYL PYRIMIDINE DERIVATIVE AS ANALGESIC AGENT | GLAXO GROUP LIMITED (GB) | 1997-03-13 | — | — | WO | claimed |
| US-5597828-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS CEREBRAL ISCHEMIC DAMAGE AND EPILEPSY | GLAXO WELLCOME INC. (US) | 1997-01-28 | — | — | US | claimed |
| EP-1681058-A2 | Pharmacologically active cns compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 2006-07-19 | — | — | EP | disclosed |
| EP-1325916-A1 | Piperazinyl-substituted phenyl pyrimidine derivatives useful in the treatment or prevention of disorders of the central nervous system | THE WELLCOME FOUNDATION LIMITED (GB) | 2003-07-09 | — | — | EP | disclosed |
| EP-0715851-B1 | Substituted phenylpyrimidine derivatives, useful in the treatment or prevention of CNS disorders | WELLCOME FOUND (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-6479498-B1 | COMPRISE 2-10 SODIUM CHANNEL LIGANDS COVALENTLY CONNECTED BY A LINKER OR LINKERS | THERAVANCE, INC. | 2002-11-12 | — | — | US | disclosed |
| US-6420354-B1 | Sodium channel drugs and uses | ADVANCED MEDICINE, INC. | 2002-07-16 | — | — | US | disclosed |
| WO-1999063984-A9 | NOVEL SODIUM CHANNEL DRUGS AND USES | — | 2002-04-25 | — | — | WO | disclosed |
| EP-0879230-B1 | OPTICALLY ACTIVE PHENYL PYRIMIDINE DERIVATIVE AS ANALGESIC AGENT | GLAXO GROUP LTD (GB) | 2001-07-25 | — | — | EP | disclosed |
| EP-0727213-A2 | Substituted phenylpyrimidine derivatives, useful in the treatment or prevention of CNS disorders | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-08-21 | — | — | EP | disclosed |
| EP-0727214-A2 | Substituted phenylpyrimidine derivatives, useful in the treatment or prevention of CNS disorders | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-08-21 | — | — | EP | disclosed |
| EP-0727212-A2 | Substituted phenylpyrimidine derivatives, useful in the treatment of prevention of CNS disorders | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-08-21 | — | — | EP | disclosed |
| EP-0715851-A2 | Substituted phenylpyrimidine derivatives, useful in the treatment of prevention of CNS disorders | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-06-12 | — | — | EP | disclosed |
| EP-0713703-A2 | Substituted phenylpyrimidine derivatives, useful in the treatment or prevention of CNS disorders | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-05-29 | — | — | EP | disclosed |
| CN-1117046-A | Method for preparing pharmaceutically active CNS compounds | WELLCOME FOUND (GB) | 1996-02-21 | — | — | CN | disclosed |
| US-5136080-A | Intermediates for glutamate inhibitors | BURROUGHS WELLCOME CO. (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0372934-A2 | Pharmacologically active CNS compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-06-13 | — | — | EP | disclosed |