Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 3/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7624240 | 0.82 | RAF1 (0.40) | RAF1MAPK14RAB9AGAANPSR1 | |
| SCHEMBL3630059 | 0.78 | CYP17A1 (0.39) | CYP17A1RAF1MAPK14ERBB2MAPK11 | |
| SCHEMBL13388916 | 0.72 | MEN1 (0.47) | CYP17A1MEN1KMT2ARAB9APOLB | |
| SCHEMBL27608792 | 0.71 | CYP17A1 (0.49) | CYP17A1TSHRMEN1KMT2ARAB9A | |
| SCHEMBL27608860 | 0.71 | CYP17A1 (0.49) | CYP17A1TSHRMEN1KMT2ARAB9A | |
| SCHEMBL667391 | 0.71 | MAPK14 (0.62) | RAF1MAPK14ERBB2MAPK11MEN1 | |
| SCHEMBL6049566 | 0.70 | MAPK14 (0.43) | CYP17A1RAF1MAPK14ERBB2MAPK11 | |
| SCHEMBL4429666 | 0.70 | RAF1 (0.52) | RAF1MAPK14MAPK11 | |
| SCHEMBL27842253 | 0.70 | MAPK14 (0.54) | CYP17A1RAF1MAPK14ERBB2MAPK11 | |
| SCHEMBL27608750 | 0.69 | ESR1 (0.47) | CYP17A1TSHRMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1041982-A4 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER PHARMACEUTICALS CORP (US) | 2006-06-14 | — | — | EP | disclosed |
| EP-1041982-A1 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | Bayer Corporation (US) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999032111-A1 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER CORPORATION (US) | 1999-07-01 | — | — | WO | disclosed |