Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 20/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 20/20 | 1.00 |
| ▸ | PDE4A | P27815 | 3/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 3/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 3/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 3/20 | 1.00 |
| ▸ | PDE2A | O00408 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | PDE1A | P54750 | 1/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.55 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ci-930 SCHEMBL10657390 | 0.99 | PDE3B (0.98) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Ci-930 SCHEMBL10994729 | 0.91 | PDE3B (0.83) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Ci-930 SCHEMBL10994723 | 0.91 | PDE3B (0.83) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Ci-930 SCHEMBL10423428 | 0.87 | PDE3B (0.76) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11206290 | 0.84 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL16157200 | 0.84 | PDE3B (0.73) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10469492 | 0.83 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL6212364 | 0.83 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL6212361 | 0.83 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL6212367 | 0.83 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1176960-B1 | SYNERGISTIC COMBINATION COMPRISING ROFLUMILAST AND A PDE-3 INHIBITOR | ALTANA PHARMA AG (DE) | 2004-09-29 | — | — | EP | claimed |
| US-4908389-A | Transmembranally administerable composition comprising procaterol, 4,5-dihydro-6-(4-(1H-imidazole-1-yl)phenyl)-5-methyl-3-(2H)-pyridazinone, hydromorphine, propanolol, morphine, chlorpheniramine, fatty compound, alcohol, triacetin | WARNER-LAMBERT COMPANY (US) | 1990-03-13 | — | — | US | claimed |
| US-4868182-A | HYPOTENSIVE AND CARDIOTONIC, SYNERGISTIC | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-19 | — | — | US | claimed |
| US-4789547-A | CROSSLINKED CARBOXYMETHYL CELLULOSE, ALCOHOL SOLUBLE POLYHYDROXYETHYL METHACRYLATE, AND PERMEATION ENHANCER | WARNER-LAMBERT COMPANY (US) | 1988-12-06 | — | — | US | claimed |
| EP-0090978-B1 | IMIDAZOLYLPHENYL-TETRAHYDROPYRIDAZINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | A. Nattermann & Cie. GmbH (DE) | 1988-11-30 | — | — | EP | claimed |
| EP-0156163-B1 | PHARMACEUTICAL PRODUCT FOR THE TREATMENT OF HYPERTENSION AND THROMBOEMBOLIC DISEASES | A. Nattermann & Cie. GmbH (DE) | 1988-11-09 | — | — | EP | claimed |
| EP-0268146-A1 | Enhancement of prazosin | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-05-25 | — | — | EP | claimed |
| US-4717730-A | HYPOTENSIVE AND CARDIOTONIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1988-01-05 | — | — | US | claimed |
| US-4551455-A | HYPOTENSIVE AGENTS | A. NATTERMANN & CIE GMBH (DE) | 1985-11-05 | — | — | US | claimed |
| EP-0156163-A1 | Pharmaceutical product for the treatment of hypertension and thromboembolic diseases | A. Nattermann & Cie. GmbH (DE) | 1985-10-02 | — | — | EP | claimed |
| EP-0090978-A2 | Imidazolylphenyl-tetrahydropyridazines, process for their preparation and pharmaceutical compositions containing them | A. Nattermann & Cie. GmbH (DE) | 1983-10-12 | — | — | EP | claimed |
| EP-0075436-A1 | Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted)phenyl-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1983-03-30 | — | — | EP | claimed |
| WO-2018026812-A1 | ANTIVIRAL AGENTS | OHIO STATE INNOVATION FOUNDATION (US) | 2018-02-08 | — | — | WO | disclosed |
| EP-1620083-A2 | COMBINATION THERAPIES | Pharmacia & Upjohn Company LLC (US) | 2006-02-01 | — | — | EP | disclosed |
| EP-1505972-A2 | A SELECTIVE INOS INHIBITOR AND A PDE INHIBITOR IN COMBINATION FOR THE TREATMENT OF RESPIRATORY DISEASES | Pharmacia Corporation (US) | 2005-02-16 | — | — | EP | disclosed |
| WO-2004091596-A2 | COMBINATION THERAPIES FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-10-28 | — | — | WO | disclosed |
| EP-0156163-A1 | Pharmaceutical product for the treatment of hypertension and thromboembolic diseases | A. Nattermann & Cie. GmbH (DE) | 1985-10-02 | — | — | EP | disclosed |
| EP-0122419-A2 | Substituted 3-mercaptopyridazines, their 3-alkylthio derivatives and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-10-24 | — | — | EP | disclosed |
| EP-0090978-A2 | Imidazolylphenyl-tetrahydropyridazines, process for their preparation and pharmaceutical compositions containing them | A. Nattermann & Cie. GmbH (DE) | 1983-10-12 | — | — | EP | disclosed |
| EP-0075436-A1 | Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted)phenyl-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1983-03-30 | — | — | EP | disclosed |