Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9940993 | 0.78 | KDM4E (0.45) | KDM4EPOLBKMT2AMAPK1L3MBTL1 | |
| SCHEMBL6053096 | 0.73 | KDM4E (0.44) | KDM4EPOLBKMT2ARAB9ANPC1 | |
| SCHEMBL1963577 | 0.69 | KDM4E (0.52) | KDM4EPOLBKMT2ARAB9ANPC1 | |
| SCHEMBL9940611 | 0.65 | PIM1 (0.49) | KDM4EKMT2ANPC1MEN1ALDH1A1 | |
| SCHEMBL30200851 | 0.65 | KDM4E (0.52) | KDM4EPOLBKMT2ARAB9ANPC1 | |
| SCHEMBL9940628 | 0.64 | MAPT (0.36) | KMT2ARAB9ANPC1MAPK1MEN1 | |
| SCHEMBL14026572 | 0.64 | KDM4E (0.55) | KDM4EPOLBKMT2ARAB9ANPC1 | |
| SCHEMBL1967202 | 0.63 | KDM4E (0.48) | KDM4EPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL4150694 | 0.63 | CCNA2 (0.40) | KDM4EKMT2ARAB9ANPC1MAPK1 | |
| SCHEMBL1967065 | 0.63 | KDM4E (0.56) | KDM4EPOLBKMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636236-A1 | PYRAZOLO-QUINAZOLINE DERIVATIVES,PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004104007-A1 | PYRAZOLO-QUINAZOLINE DERIVATIVES,PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2004-12-02 | — | — | WO | disclosed |