Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Trientine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.61 |
| ▸ | CA6 | P23280 | 5/20 | 0.61 |
| ▸ | CA7 | P43166 | 5/20 | 0.61 |
| ▸ | CA9 | Q16790 | 5/20 | 0.61 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.61 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.61 |
| ▸ | CA2 | P00918 | 4/20 | 0.61 |
| ▸ | CA4 | P22748 | 4/20 | 0.61 |
| ▸ | CA5A | P35218 | 4/20 | 0.61 |
| ▸ | CA3 | P07451 | 3/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | CA1 | P00915 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL10408733 | 1.00 | CA12 (0.61) | CA12CA6CA7CA9CA14 | |
| Trientine SCHEMBL9319697 | 1.00 | CA12 (0.61) | CA12CA6CA7CA9CA14 | |
| Acetic Acid SCHEMBL20531236 | 1.00 | CA12 (0.61) | CA12CA6CA7CA9CA14 | |
| Acetic Acid SCHEMBL28891226 | 1.00 | CA12 (0.61) | CA12CA6CA7CA9CA14 | |
| Trientine SCHEMBL159616 | 1.00 | CA12 (0.61) | CA12CA6CA7CA9CA14 | |
| Acetic Acid SCHEMBL1641749 | 1.00 | CA12 (0.61) | CA12CA6CA7CA9CA14 | |
| Trientine SCHEMBL10875300 | 1.00 | CA12 (0.61) | CA12CA6CA7CA9CA14 | |
| Trientine SCHEMBL11474494 | 0.97 | CA12 (0.58) | CA12CA6CA7CA9CA14 | |
| Trientine SCHEMBL11456308 | 0.97 | CA12 (0.58) | CA12CA6CA7CA9CA14 | |
| Trientine SCHEMBL9794969 | 0.97 | CA12 (0.58) | CA12CA6CA7CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117645615-B | Method for racemizing dextromethorphan base by using ionic liquid as catalyst | JIANGSU TIANHE PHARMACEUTICAL Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-117645615-A | Method for racemizing dextromethorphan base by using ionic liquid as catalyst | 天和药业股份有限公司 | 2024-03-05 | — | — | CN | claimed |
| WO-2023221751-A1 | PREPARATION METHOD FOR WAFFLE-SHAPED ADSORBENT COMPOSITE MATERIAL | 苏州西热节能环保技术有限公司 | 2023-11-23 | — | — | WO | claimed |
| CN-112892599-B | IL/GO/Fe-based MOFs composite photocatalytic material and preparation method and application thereof | 华南理工大学 | 2022-04-05 | — | — | CN | claimed |
| CN-112892599-A | IL/GO/Fe-based MOFs composite photocatalytic material and preparation method and application thereof | 华南理工大学 | 2021-06-04 | — | — | CN | claimed |
| CN-103450131-B | The preparation method of a kind of dehydroacetic acid (DHA) and sodium salt thereof | Nantong Acetic Acid Chemical Co., Ltd. (CN) | 2015-08-26 | — | — | CN | claimed |
| CN-103450131-A | Preparation method of dehydroacetic acid and sodium salt thereof | NANTONG ACETIC ACID CHEMICAL CO LTD | 2013-12-18 | — | — | CN | claimed |
| US-3947396-A | Coacervation of anion-containing aqueous disperse systems with amphoteric polyelectrolytes | THE DOW CHEMICAL COMPANY (US) | 1976-03-30 | — | — | US | claimed |
| CN-117645615-B | Method for racemizing dextromethorphan base by using ionic liquid as catalyst | JIANGSU TIANHE PHARMACEUTICAL Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | disclosed |
| CN-117645615-A | Method for racemizing dextromethorphan base by using ionic liquid as catalyst | 天和药业股份有限公司 | 2024-03-05 | — | — | CN | disclosed |
| WO-2023221751-A1 | PREPARATION METHOD FOR WAFFLE-SHAPED ADSORBENT COMPOSITE MATERIAL | 苏州西热节能环保技术有限公司 | 2023-11-23 | — | — | WO | disclosed |
| CN-115445575-A | Solid amine adsorbent and preparation method thereof, and carbon dioxide adsorption and regeneration method | 中国石油化工股份有限公司 | 2022-12-09 | — | — | CN | disclosed |
| CN-115025761-A | Preparation method of waffle-shaped adsorbent composite material | 苏州西热节能环保技术有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-112892599-B | IL/GO/Fe-based MOFs composite photocatalytic material and preparation method and application thereof | 华南理工大学 | 2022-04-05 | — | — | CN | disclosed |
| US-5705325-A | SUPPORT WITH MULTILAYER SILVER HALIDE EMULSIONS USING POLYSTYRENE SUPPORT | KONICA CORPORATION (JP) | 1998-01-06 | — | — | US | disclosed |
| EP-0766133-A2 | Silver halide photographic light-sensitive material | KONICA CORPORATION (JP) | 1997-04-02 | — | — | EP | disclosed |
| US-4802905-A | POLYETHYLENE OR-2,3-BUTYLENE POLYAMINES OR THEIR SALTS | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1989-02-07 | — | — | US | disclosed |
| EP-0281925-A2 | Method for protecting plants and plant matter from stress | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4608398-A | CURABLE POLYURETHANE AND LIQUID ALKANOL BLOWING AGENT, ALSO A BY-PRODUCT OF THE ALKOXYLATED AMINE CURING AGENT | NORDSON CORPORATION (US) | 1986-08-26 | — | — | US | disclosed |
| US-3947396-A | Coacervation of anion-containing aqueous disperse systems with amphoteric polyelectrolytes | THE DOW CHEMICAL COMPANY (US) | 1976-03-30 | — | — | US | disclosed |