Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 2/20 | 0.54 |
| ▸ | NPY5R | Q15761 | 14/20 | 0.51 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2657710 | 0.87 | NPY5R (0.64) | AVPR1ANPY5RDGAT1HSD11B1 | |
| SCHEMBL4577444 | 0.83 | AVPR1A (0.58) | AVPR1ANPY5R | |
| SCHEMBL6054873 | 0.82 | AVPR1A (0.54) | AVPR1ANPY5RDGAT1HSD11B1 | |
| SCHEMBL4164094 | 0.81 | NPY5R (0.79) | NPY5R | |
| SCHEMBL4016619 | 0.79 | NPY5R (0.48) | AVPR1ANPY5RDGAT1HSD11B1 | |
| SCHEMBL4577327 | 0.79 | NPY5R (0.57) | AVPR1ANPY5RDGAT1HSD11B1 | |
| SCHEMBL4577476 | 0.79 | NPY5R (0.55) | AVPR1ANPY5RDGAT1HSD11B1 | |
| SCHEMBL6054824 | 0.78 | NPY5R (0.66) | AVPR1ANPY5RDGAT1HSD11B1 | |
| SCHEMBL4577315 | 0.73 | NPY5R (0.81) | NPY5R | |
| SCHEMBL4158894 | 0.73 | NPY5R (0.79) | NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635773-A2 | COMBINATION THERAPY FOR THE TREATMENT OF HYPERTENSION | Merck & Co., Inc. (a New Jersey corp.) (US) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004110368-A2 | COMBINATION THERAPY FOR THE TREATMENT OF HYPERTENSION | MERCK & CO., INC. (US) | 2004-12-23 | — | — | WO | disclosed |