Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | PPARD | Q03181 | 3/20 | 0.40 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5990294 | 0.97 | CYP3A4 (0.44) | CYP3A4CYP2C9CYP2C19CYP1A2L3MBTL1 | |
| SCHEMBL5991150 | 0.81 | PPARG (0.51) | CYP3A4CYP2C9CYP2C19CYP1A2L3MBTL1 | |
| SCHEMBL5989704 | 0.81 | PPARG (0.56) | CYP3A4CYP2C9CYP2C19CYP1A2HTT | |
| SCHEMBL5989975 | 0.81 | PPARG (0.51) | CYP3A4CYP2C9CYP2C19CYP1A2L3MBTL1 | |
| SCHEMBL5989877 | 0.81 | PPARG (0.56) | CYP3A4CYP2C9CYP2C19CYP1A2HTT | |
| SCHEMBL5989711 | 0.81 | PPARG (0.56) | CYP3A4CYP2C9CYP2C19CYP1A2HTT | |
| SCHEMBL5989981 | 0.81 | PPARG (0.51) | CYP3A4CYP2C9CYP2C19CYP1A2L3MBTL1 | |
| SCHEMBL5640956 | 0.79 | MAPT (0.55) | CYP3A4CYP2C19CYP1A2L3MBTL1MAPT | |
| SCHEMBL5990060 | 0.78 | CYP1A2 (0.51) | CYP3A4CYP2C9CYP2C19CYP1A2L3MBTL1 | |
| SCHEMBL11270981 | 0.76 | MAPT (0.55) | CYP3A4CYP2C19CYP1A2L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660428-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019151-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-03 | — | — | WO | disclosed |