Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 7/20 | 0.68 |
| ▸ | NPC1 | O15118 | 7/20 | 0.60 |
| ▸ | RAB9A | P51151 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | KLK7 | P49862 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6058007 | 0.86 | LCK (0.92) | LCKNPC1RAB9AALDH1A1 | |
| SCHEMBL6057615 | 0.84 | LCK (0.92) | LCKNPC1RAB9AALDH1A1MAOA | |
| SCHEMBL6057934 | 0.84 | LCK (0.92) | LCKABL1 | |
| SCHEMBL6058150 | 0.82 | LCK (0.92) | LCKNPC1RAB9AALDH1A1 | |
| SCHEMBL6058002 | 0.81 | LCK (1.00) | LCKNPC1RAB9AHSP90AA1 | |
| SCHEMBL6058036 | 0.80 | LCK (1.00) | LCK | |
| SCHEMBL4917462 | 0.79 | MEN1 (0.73) | LCKNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL6057905 | 0.79 | LCK (1.00) | LCKNPC1RAB9AHSP90AA1 | |
| SCHEMBL6057733 | 0.78 | LCK (0.96) | LCK | |
| SCHEMBL6057741 | 0.78 | LCK (0.92) | LCKNPC1RAB9AHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037632-B1 | BENZOTHIAZOLE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2006-01-11 | — | — | EP | claimed |