Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.74 |
| ▸ | HTR3A | P46098 | 1/20 | 0.74 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | HTR1D | P28221 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
| ▸ | HTR7 | P34969 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2167067 | 0.86 | HRH4 (0.76) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL2166919 | 0.86 | HRH4 (0.85) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL2167865 | 0.85 | HRH4 (1.00) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| Hydrochloric Acid SCHEMBL603952 | 0.85 | HRH4 (0.82) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL2169559 | 0.85 | HRH4 (0.74) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL2168359 | 0.85 | HRH4 (0.74) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL603164 | 0.84 | HRH4 (0.69) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL605487 | 0.84 | HRH4 (0.69) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL2166566 | 0.83 | HRH4 (0.94) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL604950 | 0.82 | HRH4 (0.70) | HRH4HTR3AHTR1AADRA2AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654237-A1 | 2-AMINOPYRIMIDINE DERIVATIVES | Bayer HealthCare AG (DE) | 2006-05-10 | — | — | EP | claimed |
| WO-2005014556-A1 | 2-AMINOPYRIMIDINE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2005-02-17 | — | — | WO | claimed |
| EP-1505064-A1 | 2-Aminopyrimidine derivatives | Bayer HealthCare AG (DE) | 2005-02-09 | — | — | EP | claimed |
| US-10195195-B2 | Selective histamine H4 receptor antagonists for the treatment of vestibular disorders | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2019-02-05 | — | — | US | disclosed |
| EP-3378476-A1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | Sensorion (FR) | 2018-09-26 | — | — | EP | disclosed |
| US-9688989-B2 | H4 receptor inhibitors for treating tinnitus | SENSORION (FR) | 2017-06-27 | — | — | US | disclosed |
| US-20170056397-A1 | SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2017-03-02 | — | — | US | disclosed |
| EP-3130376-A1 | SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2017-02-15 | — | — | EP | disclosed |
| US-9526725-B2 | Selective histamine H4 receptor antagonists for the treatment of vestibular disorders | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2016-12-27 | — | — | US | disclosed |
| EP-2382013-B1 | SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS. | INSERM INST NAT DE LA SANTÉ ET DE LA RECH MÉDICALE (FR) | 2016-07-13 | — | — | EP | disclosed |
| US-20150176010-A1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | SENSORION (FR) | 2015-06-25 | — | — | US | disclosed |
| CN-104582703-A | H4 receptor inhibitors for treating tinnitus | SENSORION | 2015-04-29 | — | — | CN | disclosed |
| US-20120039913-A1 | Selective Histamine H4 Receptor Antagonists for the Treatment of Vestibular Disorders | INSERM (institut National de la Sante de la Recher Medicale) (FR) | 2012-02-16 | — | — | US | disclosed |
| EP-2382013-A1 | SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS. | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010072829-A1 | SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS. | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2010-07-01 | — | — | WO | disclosed |
| EP-1654237-A1 | 2-AMINOPYRIMIDINE DERIVATIVES | Bayer HealthCare AG (DE) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005014556-A1 | 2-AMINOPYRIMIDINE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2005-02-17 | — | — | WO | disclosed |
| EP-1505064-A1 | 2-Aminopyrimidine derivatives | Bayer HealthCare AG (DE) | 2005-02-09 | — | — | EP | disclosed |