Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 7/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | CCR2 | P41597 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6058886 | 0.95 | NR3C2 (0.43) | NR3C2IGF1RPKMCYP17A1MAPK14 | |
| SCHEMBL5079952 | 0.88 | NR3C2 (0.48) | NR3C2IGF1RCYP17A1CCR2PPARG | |
| SCHEMBL190869 | 0.83 | IGF1R (0.44) | NR3C2IGF1RPKMCYP17A1MAPK14 | |
| SCHEMBL6058814 | 0.83 | IGF1R (0.40) | NR3C2IGF1RPKMCYP17A1MAPK14 | |
| SCHEMBL12596578 | 0.83 | NR3C2 (0.47) | NR3C2IGF1RCYP17A1CCR2 | |
| SCHEMBL12540360 | 0.83 | NR3C2 (0.47) | NR3C2IGF1RCYP17A1CCR2 | |
| SCHEMBL6058884 | 0.83 | NR3C2 (0.42) | NR3C2IGF1RCYP17A1MAPK14CCR2 | |
| SCHEMBL15354529 | 0.82 | RIOK2 (0.50) | NR3C2IGF1RPKMCYP17A1MAPK14 | |
| SCHEMBL6058751 | 0.82 | NAMPT (0.44) | PKMCYP17A1ALDH1A1GAAMKNK2 | |
| SCHEMBL21999119 | 0.81 | NR3C2 (0.44) | NR3C2IGF1RCYP17A1CCR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071175-B1 | Pyridine mercapto carboxylic acids as carboxypeptidase U inhibitors | ASTRAZENECA AB (SE) | 2006-07-04 | — | — | US | disclosed |
| EP-1180098-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2002-02-20 | — | — | EP | disclosed |
| WO-2000066557-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-09 | — | — | WO | disclosed |