Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 17/20 | 0.61 |
| ▸ | ESR2 | Q92731 | 17/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.59 |
| ▸ | MLNR | O43193 | 1/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.57 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | NPY1R | P25929 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6058984 | 1.00 | ESR1 (0.61) | ESR1ESR2HRH3MLNRNR1I2 | |
| SCHEMBL6058988 | 1.00 | ESR1 (0.61) | ESR1ESR2HRH3MLNRNR1I2 | |
| SCHEMBL8103607 | 0.85 | ESR1 (0.64) | ESR1ESR2HRH3MLNRNR1I2 | |
| SCHEMBL1359959 | 0.81 | ESR1 (0.76) | ESR1ESR2HRH3 | |
| SCHEMBL699174 | 0.81 | ESR1 (0.76) | ESR1ESR2HRH3 | |
| SCHEMBL31402365 | 0.80 | ESR1 (0.62) | ESR1ESR2 | |
| SCHEMBL2475993 | 0.79 | ESR1 (0.75) | ESR1ESR2HRH3PTGS2 | |
| SCHEMBL6678781 | 0.78 | ESR1 (0.89) | ESR1ESR2HRH3MLNRNR1I2 | |
| SCHEMBL282198 | 0.78 | ESR1 (0.89) | ESR1ESR2HRH3MLNRNR1I2 | |
| SCHEMBL668296 | 0.78 | ESR1 (0.89) | ESR1ESR2HRH3MLNRNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021410-B1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER (US) | 2006-12-27 | — | — | EP | disclosed |