Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 11/20 | 0.67 |
| ▸ | THRB | P10828 | 8/20 | 0.50 |
| ▸ | THRA | P10827 | 6/20 | 0.50 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | ASPH | Q12797 | 1/20 | 0.50 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.50 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.50 |
| ▸ | EGLN2 | Q96KS0 | 4/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16820450 | 0.88 | EGLN1 (0.65) | EGLN1THRBTHRABBOX1SLC6A2 | |
| SCHEMBL15547320 | 0.84 | EGLN1 (0.94) | EGLN1THRBTHRABBOX1SLC6A2 | |
| SCHEMBL16820470 | 0.84 | EGLN1 (0.70) | EGLN1THRBTHRABBOX1SLC6A2 | |
| SCHEMBL522819 | 0.82 | EGLN1 (0.58) | EGLN1THRBTHRABBOX1SLC6A2 | |
| SCHEMBL14672078 | 0.82 | EGLN1 (0.71) | EGLN1THRBTHRABBOX1SLC6A2 | |
| SCHEMBL522957 | 0.81 | EGLN1 (1.00) | EGLN1THRBTHRABBOX1SLC6A2 | |
| SCHEMBL523599 | 0.79 | EGLN1 (0.63) | EGLN1THRBTHRABBOX1SLC6A2 | |
| SCHEMBL15549348 | 0.76 | EGLN1 (0.70) | EGLN1THRBTHRABBOX1SLC6A2 | |
| SCHEMBL5316412 | 0.76 | EGLN1 (0.57) | EGLN1THRBTHRABBOX1SLC6A2 | |
| SCHEMBL16841134 | 0.74 | EGLN1 (0.60) | EGLN1THRBTHRABBOX1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644336-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN | FIBROGEN, INC. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2004108681-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENOUS ERYTHROPOIETIN | FIBROGEN, INC. (US) | 2004-12-16 | — | — | WO | disclosed |