Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.39 |
| ▸ | SNCA | P37840 | 2/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | ACP3 | P15309 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6061532 | 0.96 | SNCA (0.44) | SNCATAAR1SLC6A2MAOASLC6A4 | |
| Iodide SCHEMBL6061684 | 0.96 | SNCA (0.44) | SNCATAAR1SLC6A2MAOASLC6A4 | |
| Bromide SCHEMBL2646998 | 0.93 | SNCA (0.47) | SNCATAAR1SLC6A2MAOASLC6A4 | |
| Bromide SCHEMBL7197866 | 0.89 | SNCA (0.43) | SNCATAAR1ACHEIDO1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL29427125 | 0.89 | SNCA (0.44) | SNCATAAR1SLC6A2MAOASLC6A4 | |
| Hydrochloric Acid SCHEMBL2447879 | 0.89 | SNCA (0.44) | SNCATAAR1SLC6A2MAOASLC6A4 | |
| Phosphoric Acid SCHEMBL7197899 | 0.89 | ACP3 (0.43) | SNCAPPARGPPARAACP3POLB | |
| Acetic Acid SCHEMBL8750035 | 0.87 | SNCA (0.41) | SNCAPPARGPPARAACP3POLB | |
| Acetic Acid SCHEMBL7193257 | 0.86 | SNCA (0.41) | SNCAPPARGPPARAACP3POLB | |
| Hydrochloric Acid SCHEMBL7199763 | 0.85 | SNCA (0.41) | SNCATAAR1ACHEIDO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993004122-A1 | POLYESTER COMPOSITIONS CONTAINING PHOSPHONIUM COMPOUNDS | THE DOW CHEMICAL COMPANY (US) | 1993-03-04 | — | — | WO | claimed |
| US-20060229400-A1 | Powder coating matting agent comprising ester amide condensation product | FLETCHER TIM | 2006-10-12 | — | — | US | disclosed |
| US-20050288450-A1 | Coating matting agent comprising amide condensation product | FLETCHER TIM | 2005-12-29 | — | — | US | disclosed |
| EP-1509561-A1 | POWDER COATING MATTING AGENT COMPRISING ESTER AMIDE CONDENSATION PRODUCT | Grace GmbH & Co. KG (DE) | 2005-03-02 | — | — | EP | disclosed |
| WO-2003102048-A1 | POWDER COATING MATTING AGENT COMPRISING ESTER AMIDE CONDENSATION PRODUCT | GRACE GMBH & CO. KG (DE) | 2003-12-11 | — | — | WO | disclosed |
| EP-0624173-B2 | PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS | DOW CHEMICAL CO (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-0624173-B1 | PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS | DOW CHEMICAL CO (US) | 1997-04-02 | — | — | EP | disclosed |
| EP-0624173-A1 | PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS. | DOW CHEMICAL CO (US) | 1994-11-17 | — | — | EP | disclosed |
| US-5360886-A | Alklyphenylphosphine or phosphonium catalyst | THE DOW CHEMICAL COMPANY (US) | 1994-11-01 | — | — | US | disclosed |
| US-5310853-A | Epoxy resins | THE DOW CHEMICAL COMPANY (US) | 1994-05-10 | — | — | US | disclosed |
| WO-1993015126-A1 | PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS | THE DOW CHEMICAL COMPANY (US) | 1993-08-05 | — | — | WO | disclosed |
| US-5202407-A | Phosphonium or phosphine catalyst having at least three alkylphenyl groups attached to phosphorus atom | THE DOW CHEMICAL COMPANY (US) | 1993-04-13 | — | — | US | disclosed |
| WO-1993004122-A1 | POLYESTER COMPOSITIONS CONTAINING PHOSPHONIUM COMPOUNDS | THE DOW CHEMICAL COMPANY (US) | 1993-03-04 | — | — | WO | disclosed |