SCHEMBL6061609

SCHEMBL6061609

O=C(CCCCNC(=O)[C@H](CS(=O)(=O)Cc1ccccc1)Nc1ncc([N+](=O)[O-])s1)c1nc2ccccc2o1

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.47
KMT2A Q03164 4/20 0.47
RAB9A P51151 2/20 0.47
DAGLA Q9Y4D2 5/20 0.43
FAAH O00519 3/20 0.43
CES1 P23141 2/20 0.43
ATG4B Q9Y4P1 9/20 0.42
MAPT P10636 2/20 0.39
CDK2 P24941 1/20 0.39
GSK3A P49840 1/20 0.39
GSK3B P49841 1/20 0.39
DYRK1A Q13627 1/20 0.39
HIPK4 Q8NE63 1/20 0.39
CLK4 Q9HAZ1 1/20 0.39
NPC1 O15118 1/20 0.39
HTT P42858 1/20 0.39
ALDH1A1 P00352 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6063027 0.84 DAGLA (0.44) RAB9ADAGLAFAAHCES1NPC1
SCHEMBL6630842 0.82 MEN1 (0.44) MEN1KMT2ARAB9AATG4BMAPT
SCHEMBL6061605 0.82 MEN1 (0.44) MEN1KMT2ARAB9AATG4BMAPT
SCHEMBL6061646 0.80 DAGLA (0.48) DAGLAFAAHCES1ALDH1A1
SCHEMBL6062834 0.80 DAGLA (0.56) DAGLAFAAHCES1ALDH1A1
SCHEMBL6062952 0.79 DAGLA (0.52) DAGLAFAAHCES1ALDH1A1
SCHEMBL6630749 0.76 DAGLA (0.53) DAGLAFAAHCES1ALDH1A1
SCHEMBL6630904 0.76 DAGLA (0.46) RAB9ADAGLAFAAHCES1NPC1
SCHEMBL6631047 0.76 DAGLA (0.52) DAGLAFAAHCES1ALDH1A1
SCHEMBL6061806 0.76 DAGLA (0.48) DAGLAFAAHCES1MAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1397340-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2004-03-17 EP claimed
WO-2002098850-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-12-12 WO claimed
EP-1694357-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2006-08-30 EP disclosed
WO-2005058348-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2005-06-30 WO disclosed
EP-1397340-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2004-03-17 EP disclosed
WO-2002098850-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-12-12 WO disclosed