Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.46 |
| ▸ | MAPK7 | Q13164 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL298823 | 0.98 | MAPK14 (0.46) | MAPK14MAPK7HTTALDH1A1LMNA | |
| SCHEMBL297517 | 0.96 | MAPK14 (0.47) | MAPK14MAPK7HTTALDH1A1LMNA | |
| SCHEMBL13075046 | 0.89 | MAPK14 (0.55) | MAPK14MAPK7HTTALDH1A1LMNA | |
| SCHEMBL10042044 | 0.82 | MAPK14 (0.50) | MAPK14MAPK7HTTALDH1A1LMNA | |
| SCHEMBL10042082 | 0.80 | MAPK14 (0.48) | MAPK14MAPK7HTTALDH1A1 | |
| SCHEMBL10042083 | 0.80 | MAPK14 (0.48) | MAPK14MAPK7HTT | |
| SCHEMBL607787 | 0.80 | MAPK14 (0.48) | MAPK14MAPK7HTTLMNAMEN1 | |
| SCHEMBL607888 | 0.79 | MAPK14 (0.46) | MAPK14MAPK7HTTALDH1A1MEN1 | |
| SCHEMBL606459 | 0.79 | MAPK14 (0.52) | MAPK14MAPK7HTTCYP1A2CYP2C9 | |
| SCHEMBL615900 | 0.78 | MAPK14 (0.56) | MAPK14MAPK7HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513289-B2 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. (US) | 2013-08-20 | — | — | US | disclosed |
| US-8513289-B2 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. (US) | 2013-08-20 | — | — | US | disclosed |
| US-8513289-B2 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. (US) | 2013-08-20 | — | — | US | disclosed |
| US-20120040999-A1 | P38 KINASE INHIBITING AGENTS | MERCK SHARP & DOHME LLC | 2012-02-16 | — | — | US | disclosed |
| US-20120040999-A1 | P38 KINASE INHIBITING AGENTS | MERCK SHARP & DOHME LLC | 2012-02-16 | — | — | US | disclosed |
| US-20120040999-A1 | P38 KINASE INHIBITING AGENTS | MERCK SHARP & DOHME LLC | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040999-A1 | P38 KINASE INHIBITING AGENTS | MAPK1, MAPK8, MAPKAPK2 | MAPK14 13/4885MAPK7 4/4885HTT 3782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.