Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3871684 | 0.82 | TSHR (0.48) | MAPTPOLBTSHRCYP3A4L3MBTL1 | |
| SCHEMBL1598194 | 0.81 | MAPT (0.50) | MAPTPOLBTSHRL3MBTL1MEN1 | |
| SCHEMBL14547540 | 0.78 | MAPT (0.39) | MAPTPOLBTSHRCYP3A4L3MBTL1 | |
| Barbituric Acid SCHEMBL8741420 | 0.71 | MAPT (0.41) | MAPTPOLBL3MBTL1MEN1KMT2A | |
| SCHEMBL11500353 | 0.69 | GAA (0.54) | MAPTPOLBTSHRL3MBTL1MEN1 | |
| SCHEMBL9212290 | 0.69 | TSHR (0.69) | TSHRL3MBTL1MEN1KMT2AGSK3A | |
| SCHEMBL10977047 | 0.69 | POLB (0.43) | MAPTPOLBCYP3A4L3MBTL1MEN1 | |
| SCHEMBL8903951 | 0.68 | CYP3A4 (0.46) | MAPTPOLBTSHRCYP3A4L3MBTL1 | |
| SCHEMBL288566 | 0.68 | CYP3A4 (0.46) | MAPTPOLBTSHRCYP3A4L3MBTL1 | |
| SCHEMBL16116448 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648452-A1 | 2-IMINO-4-(THIO)OXO-5-POLYCYCLOVINYLAZOLINES FOR USE AS PI3 KINASE INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005011686-A1 | 2-IMINO-4-(THIO) OXO-5-POLY CYCLOVINYLAZOLINES FOR USE AS P13 KINASE IHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2005-02-10 | — | — | WO | disclosed |