Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | PRKCG | P05129 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | PRKX | P51817 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4020628 | 0.94 | TRPV1 (0.62) | TRPV1CLK4MAPK1AURKADYRK3 | |
| SCHEMBL4021300 | 0.82 | TRPV1 (0.71) | TRPV1CLK4 | |
| SCHEMBL6066297 | 0.80 | TRPV1 (0.65) | TRPV1CLK4 | |
| SCHEMBL4107305 | 0.78 | KDM4E (0.66) | TRPV1CLK4MAPK1ROCK2GSK3B | |
| SCHEMBL4023690 | 0.77 | CLK4 (0.52) | TRPV1CLK4MAPK1ROCK2PRKACA | |
| SCHEMBL4026162 | 0.77 | CLK4 (0.78) | TRPV1CLK4MAPK1AURKADYRK3 | |
| SCHEMBL6308037 | 0.76 | TRPV1 (0.75) | TRPV1MEN1RAB9AKMT2A | |
| SCHEMBL6066275 | 0.75 | TRPV1 (0.63) | TRPV1MEN1RAB9AKMT2A | |
| SCHEMBL6066028 | 0.75 | TRPV1 (0.65) | TRPV1 | |
| SCHEMBL4026095 | 0.74 | TRPV1 (0.55) | TRPV1CLK4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660455-A1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005016890-A1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2005-02-24 | — | — | WO | disclosed |