Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 13/20 | 0.81 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | SGK1 | O00141 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | ULK1 | O75385 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | GRK2 | P25098 | 1/20 | 0.48 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.48 |
| ▸ | GRK3 | P35626 | 1/20 | 0.48 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.48 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5016045 | 1.00 | TRPV1 (0.81) | TRPV1CLK4MAPK1SGK1ROCK2 | |
| SCHEMBL6531158 | 0.78 | TRPV1 (0.64) | TRPV1CLK4DHPSNPC1LMNA | |
| SCHEMBL4022393 | 0.77 | TRPV1 (1.00) | TRPV1CLK4GSK3BCDK7ROCK1 | |
| SCHEMBL4019196 | 0.77 | TRPV1 (1.00) | TRPV1CLK4GSK3BCDK7ROCK1 | |
| SCHEMBL3617002 | 0.77 | TRPV1 (0.63) | TRPV1MAPK1 | |
| SCHEMBL4022067 | 0.77 | TRPV1 (1.00) | TRPV1CLK4GSK3BCDK7ROCK1 | |
| SCHEMBL4023593 | 0.77 | CLK4 (0.79) | TRPV1CLK4ROCK2PRKG2ROCK1 | |
| SCHEMBL11949095 | 0.76 | TRPV1 (0.62) | TRPV1CLK4DHPSNPC1LMNA | |
| Hydrochloric Acid SCHEMBL4028497 | 0.76 | CLK4 (0.77) | TRPV1CLK4ROCK2PRKG2ROCK1 | |
| SCHEMBL4022169 | 0.76 | TRPV1 (0.70) | TRPV1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660455-A1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005016890-A1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2005-02-24 | — | — | WO | disclosed |