Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | IDO1 | P14902 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | ABCC9 | O60706 | 4/20 | 0.49 |
| ▸ | KCNJ11 | Q14654 | 4/20 | 0.49 |
| ▸ | DHODH | Q02127 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6068382 | 0.84 | IDO1 (0.55) | HTTIDO1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5449567 | 0.83 | IDO1 (0.78) | HTTIDO1MAPTALDH1A1GAA | |
| SCHEMBL28438914 | 0.83 | IDO1 (0.62) | HTTIDO1MAPTALDH1A1MEN1 | |
| SCHEMBL11729153 | 0.82 | IDO1 (0.53) | HTTIDO1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11729157 | 0.82 | IDO1 (0.53) | HTTIDO1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL10514730 | 0.80 | IDO1 (0.68) | HTTIDO1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL14586313 | 0.79 | MEN1 (0.62) | HTTIDO1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL6068221 | 0.79 | IDO1 (0.57) | IDO1MAPTALDH1A1ABCC9KCNJ11 | |
| SCHEMBL8956175 | 0.79 | IDO1 (0.66) | HTTIDO1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL6068057 | 0.78 | IDO1 (0.55) | HTTIDO1MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0392802-A2 | Preparation of urea analogues and their use in bronchial, cerebrovascular and neuronal disorders | Beecham Group p.l.c. (GB) | 1990-10-17 | — | — | EP | claimed |
| US-7115620-B2 | 1,3-disubstituted-2-thioxo-imidazolidine-4,5-diones as potassium channel openers | WYETH (US) | 2006-10-03 | — | — | US | disclosed |
| US-20030119890-A1 | 1,3-Disubstituted-2-thioxo-imidazolidine-4,5-diones as potassium channel openers | WYETH (US) | 2003-06-26 | — | — | US | disclosed |
| EP-0392802-A2 | Preparation of urea analogues and their use in bronchial, cerebrovascular and neuronal disorders | Beecham Group p.l.c. (GB) | 1990-10-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119890-A1 | 1,3-Disubstituted-2-thioxo-imidazolidine-4,5-diones as potassium channel openers | KCNJ2, KCNJ1, KCNN1 | HTT 1315/4885IDO1 1748/4885MAPT 3916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.