Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.77 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.54 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | GALR2 | O43603 | 1/20 | 0.47 |
| ▸ | GALR1 | P47211 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29408482 | 0.89 | PDE5A (0.85) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL28567178 | 0.89 | PDE5A (0.85) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL29408509 | 0.87 | PDE5A (1.00) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL29831637 | 0.87 | PDE5A (0.84) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL28564661 | 0.87 | PDE5A (1.00) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL6068495 | 0.87 | PDE5A (0.84) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL6068414 | 0.85 | PDE5A (0.79) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL2679834 | 0.84 | PDE5A (0.91) | PDE5APDE3BPDE3APDE2AGALR2 | |
| Trifluoroacetic Acid SCHEMBL29408546 | 0.84 | PDE5A (0.91) | PDE5APDE3BPDE3APDE2AGALR2 | |
| SCHEMBL29408508 | 0.82 | PDE5A (0.74) | PDE5APDE3BPDE3APDE2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087614-B2 | Pyrimidine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2006-08-08 | — | — | US | disclosed |
| US-20030162802-A1 | Pyrimidine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB COMPANY | 2003-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162802-A1 | Pyrimidine inhibitors of phosphodiesterase (PDE) 7 | PDE7A, PDE7B, PDE3A | PDE5A 5/4885PDE3B 6/4885PDE3A 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.