Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 7/20 | 0.67 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | PDE2A | O00408 | 2/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6068436 | 0.94 | PDE5A (0.67) | PDE5AAURKAPDE2APDE3BPDE3A | |
| SCHEMBL6068442 | 0.91 | PDE5A (0.68) | PDE5APDE2APDE3BPDE3ANPSR1 | |
| SCHEMBL5522619 | 0.90 | PDE5A (0.74) | PDE5AAURKAPDE2APDE3BPDE3A | |
| SCHEMBL24133172 | 0.90 | PDE5A (0.73) | PDE5AAURKAPDE2APDE3BPDE3A | |
| SCHEMBL6068033 | 0.89 | PDE5A (0.67) | PDE5APDE2APDE3BPDE3ANPSR1 | |
| SCHEMBL6068612 | 0.89 | PDE5A (0.84) | PDE5AAURKAPDE2APDE3BPDE3A | |
| SCHEMBL28564066 | 0.87 | PDE5A (0.67) | PDE5APDE2APDE3BPDE3ANPSR1 | |
| SCHEMBL29408524 | 0.87 | PDE5A (0.67) | PDE5APDE2APDE3BPDE3ANPSR1 | |
| SCHEMBL6068277 | 0.86 | PDE5A (0.65) | PDE5APDE2APDE3BPDE3ANPSR1 | |
| SCHEMBL29831637 | 0.85 | PDE5A (0.84) | PDE5AAURKAPDE2APDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087614-B2 | Pyrimidine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2006-08-08 | — | — | US | disclosed |