Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29831936 | 0.92 | PDE5A (0.70) | PDE5APIK3CBPIK3CAAURKAALDH1A1 | |
| SCHEMBL28578234 | 0.92 | PDE5A (0.70) | PDE5APIK3CBPIK3CAAURKAALDH1A1 | |
| SCHEMBL299684 | 0.91 | PDE5A (0.70) | PDE5APIK3CBPIK3CAAURKAKDM4E | |
| SCHEMBL26647635 | 0.91 | PDE5A (0.62) | PDE5AAURKA | |
| SCHEMBL289823 | 0.90 | PDE5A (0.58) | PDE5AAURKAALDH1A1KDM4ETSHR | |
| SCHEMBL290275 | 0.89 | PDE5A (0.57) | PDE5AAURKAALDH1A1KDM4ETSHR | |
| SCHEMBL291065 | 0.88 | PDE5A (0.58) | PDE5AAURKAALDH1A1KDM4ETSHR | |
| SCHEMBL291323 | 0.88 | PDE5A (0.56) | PDE5AALDH1A1KDM4ETSHRMAPT | |
| SCHEMBL27950935 | 0.84 | PDE5A (0.49) | PDE5APIK3CBPIK3CAALDH1A1KDM4E | |
| SCHEMBL291180 | 0.84 | PDE5A (0.54) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087614-B2 | Pyrimidine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2006-08-08 | — | — | US | disclosed |