Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.47 |
| ▸ | JAK1 | P23458 | 9/20 | 0.47 |
| ▸ | TYK2 | P29597 | 9/20 | 0.47 |
| ▸ | JAK3 | P52333 | 8/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6407476 | 0.92 | JAK2 (0.52) | JAK2JAK1TYK2JAK3KCNH2 | |
| SCHEMBL5458391 | 0.79 | JAK2 (0.75) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL6068379 | 0.77 | JAK2 (0.52) | JAK2JAK1TYK2JAK3NPC1 | |
| SCHEMBL3510941 | 0.72 | CHEK1 (0.56) | JAK2JAK1TYK2JAK3KCNH2 | |
| SCHEMBL1926925 | 0.72 | IKBKB (0.56) | JAK2HRH3PARP1RAB9A | |
| SCHEMBL11907261 | 0.71 | PARP1 (0.59) | JAK2HRH3PARP1HTTSMN1; SMN2 | |
| SCHEMBL30508238 | 0.69 | LRRK2 (0.57) | JAK2HRH3 | |
| SCHEMBL6401995 | 0.68 | JAK2 (0.51) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL27586651 | 0.68 | HTT (0.46) | HRH3NPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL254490 | 0.68 | HRH3 (0.72) | HRH3NPC1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135470-B2 | Thienopyridazines as IKK inhibitors | ROCHE PALO ALTO LLC (US) | 2006-11-14 | — | — | US | disclosed |