Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290607 | 0.93 | PDE5A (0.44) | PDE5AMAPTDHODHVNN1ALK | |
| SCHEMBL29408511 | 0.87 | PDE5A (0.69) | PDE5ATP53MAPTALDH1A1KDM4E | |
| SCHEMBL6068350 | 0.87 | PDE5A (0.69) | PDE5ATP53MAPTALDH1A1KDM4E | |
| SCHEMBL29408545 | 0.86 | PDE5A (0.60) | PDE5ATP53MAPTALDH1A1KDM4E | |
| SCHEMBL6068408 | 0.86 | PDE5A (0.60) | PDE5ATP53MAPTALDH1A1KDM4E | |
| SCHEMBL29408487 | 0.86 | PDE5A (0.60) | PDE5ATP53MAPTALDH1A1KDM4E | |
| SCHEMBL6068405 | 0.86 | PDE5A (0.60) | PDE5ATP53MAPTALDH1A1KDM4E | |
| SCHEMBL29408541 | 0.85 | PDE5A (0.73) | PDE5ATP53MAPTALDH1A1KDM4E | |
| SCHEMBL28565216 | 0.85 | PDE5A (0.73) | PDE5ATP53MAPTALDH1A1KDM4E | |
| SCHEMBL2680815 | 0.85 | PDE5A (0.73) | PDE5ATP53MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087614-B2 | Pyrimidine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2006-08-08 | — | — | US | disclosed |